Google DeepMind Releases AlphaGenome

Summary

Science AlphaGenome: AI for better understanding the genome Published 25 June 2025 Authors Ziga Avsec and Natasha Latysheva Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.The genome is our cellular instruction manual. It’s the complete set of DNA which guides nearly every part of a living organism, from appearance and function to growth and reproduction. Small variations in a genome’s DNA sequence can alter an organism’s response to its environment or its susceptibility to disease. But deciphering how the genome’s instructions are read at the molecular level — and what happens when a small DNA variation occurs — is still one of biology’s greatest mysteries.Today, we introduce AlphaGenome, a new artificial intelligence (AI) tool that more comprehensively and accurately predicts how single variants or mutations in human DNA sequences impact a wide range of biological processes regulating genes. This was enabled, among other factors, by technical advances allowing the model to process long DNA sequences and output high-resolution predictions.To advance scientific research, we’re making AlphaGenome available in preview via our AlphaGenome API for non-commercial research, and planning to release the model in the future.We believe AlphaGenome can be a valuable resource for the scientific community, helping scientists better understand genome function, disease biology, and ultimately, drive new biological discoveries and the development of new treatments.How AlphaGenome worksOur AlphaGenome model takes a long DNA sequence as input — up to 1 million letters, also known as base-pairs — and predicts thousands of molecular properties characterising its regulatory activity. It can also score the effects of genetic variants or mutations by comparing predictions of mutated sequences with unmutated ones.Predicted properties include where genes start and wher...