What Can a Cell Remember?

Summary

Then, in a process Kukushkin described as a tedious choreography of clockwork pipetting, they exposed the cells to precisely timed bursts of chemicals that imitated bursts of neurotransmitters in the brain. Kukushkin’s team found that the both the nerve and kidney cells could finely differentiate these patterns. A steady three-minute burst activated CRE, making the cells glow for a few hours. But the same amount of chemicals, delivered as four shorter pulses spaced 10 minutes apart, lit up the petri dish for over a day, indicating a lasting imprint — a memory. Kukushkin’s findings suggest that nonneural cells can count and detect patterns. Even though they can’t do it at the speed of a neuron, they do remember, and they appear to remember a stimulus for longer when it is delivered at spaced intervals — a hallmark of memory formation in all animals. Intuitively, this makes sense, Gershman said. From the perspective of the cell, or any other living system that shows the spacing effect, spaced information is evidence of a fairly consistent, slow-moving environment: a steady world. Massed information, on the other hand — a singular burst of chemicals or an all-night cram session — might represent a fluky event in a more chaotic environment. “If the world is changing really fast, you should forget things [more easily], because the things that you learned are going to have a shorter shelf life,” Gershman said. “They’re not going to be as useful later on, because the world will have changed.” These dynamics are as relevant to a cell’s existence as they are to ours. A vaccination is a kind of memory. So is a scar, a child, a book. Kukushkin, who has recently taken to calling himself a “molecular philosopher,” is fairly certain his findings would have been the same regardless of the type of cell he used. “I’m accepting bets for anybody’s favorite cell line showing a spacing effect,” he said. “I think it should be the default assumption that memory is a continuous process — t...